Allografts

Nerve allografts - a review

In axonotmesis, peripheral nerve regeneration, target reinnervation and recovery of function happen remarkably well with a conservative management in most of the cases. Also, substantial axonal regrowth and nerve regeneration can occur with nerve transection injuries after primary end-to-end neurorrhaphy. Nearly similar outcomes can be obtained using a nerve autograft to repair a nerve defect b...

111 Autografts and Allografts

Aortic valve allografts in sheep.

Some of the mechanical and biological problems surrounding the use of fresh allograft inverted aortic valves as mitral valve substitutes are described. Certain aspects of the problem have been studied expzrimentally. In three sheep 'fresh' aortic valve allografts were-inserted, using cardio-pulmonary bypass, into the main pulmonary artery, and were observed from 5 to 7 months after operation. T...

Thrombotic Microangiopathy in Renal Allografts

The term “thrombotic microangiopathy” (TMA) encompasses non-inflammatory small vessel vasculopathies that are caused by severe endothelial and medial smooth muscle cell injury/necrosis. TMAs can be promoted by a variety of “toxic” stimuli ranging from malignant range hypertension, E. coli infections with bloody diarrhea, radiation, systemic diseases such as scleroderma to iatrogenic events such...

Extended-donor criteria liver allografts.

Extended-donor criteria liver allografts do not meet traditional criteria for transplantation. Although these organs offer immediate expansion of the donor pool, transplantation of extended-donor criteria liver allografts increases potential short- and long-term risk to the recipient. This risk may manifest as impaired allograft function or donor-transmitted disease. Guidelines defining this ca...